Our academic research, coupled with existing clinical studies on the market, has enabled us to fine-tune the choice of molecule combinations for our formula. This combination provides a synergistic effect on joints.

Dosages have been chosen to give maximum results on the joints of the human body. As a guide, taking less than 9 grams of collagen or 1.5 g of hyaluronic acid has no significant long-term effects.

Collagen is produced in the joints by cells called chondrocytes and is composed of amino acids such as glycine, proline, and hydroxyproline. There are at least 28 different types of collagen in the human body, each with a different structure and function.

There are different types of collagen in the human body, each with a specific structure and function. Here are the most common types of collagen and their roles in the body:

• Type I collagen: This is the most abundant type of collagen in the human body. It is found in bones, skin, tendons, ligaments, and teeth. It is important for the strength and elasticity of tissues.

• Type II collagen: This is the most abundant type of collagen in cartilage. It is important for the strength and flexibility of cartilage, which covers the ends of bones in joints.

• Type III collagen: This type of collagen is found in the skin, blood vessels, muscles, and internal organs. It is important for the structure and function of soft tissues.

• Type IV collagen: This type of collagen is found in the basement membrane, which is a thin layer of tissue that separates epithelial cells from connective tissues.

• Type V collagen: This type of collagen is found in connective tissues, including muscles, tendons, and ligaments. Type V collagen is not present in Synergy6 as it does not exist in raw material form.

• Collagen has beneficial properties for joint and bone health. It is the main source of strength and mechanical resistance in cartilage. Collagen forms a matrix of insoluble fibers that provide structural support to cartilage tissue. In tendons, collagen fibers are organized into parallel bundles that give tendons their mechanical strength and ability to withstand high mechanical stress.

• Collagen is important for joint health. It is a key component of cartilage and tendons. Cartilage covers the ends of bones in joints, acting as a shock absorber for the joints and helping protect bones from wear and tear. Tendons are the junctions between bone and muscle, allowing joint mobility by transferring force from muscle to bone. Over time, collagen production in the body naturally decreases, which can lead to cartilage degradation and a loss of elasticity and firmness, associated with joint pain. With age, intrinsic changes in tendons, such as decreased collagen synthesis or water and proteoglycan content, can impair the tendons’ ability to adapt and repair.

Native collagen is the form of collagen naturally found in the body. It consists of a specific triple-helix structure, which is difficult for the body to assimilate. This is why hydrolyzed collagen, also known as collagen peptides, is increasingly used in supplementation. It is obtained by subjecting native collagen to a fragmentation process called hydrolysis. This cuts the long collagen molecule chains into smaller molecules called peptides, which are easier for the body to digest and absorb. It has been scientifically proven that these peptides help reduce joint pain and have an anti-inflammatory and protective effect on chondrocytes and cartilage

Peptan® is a type I marine collagen & Colartix® a type II bovine collagen.

There are no solid scientific studies demonstrating the superiority of one type of collagen over another. The reason is simple: the molecule is strictly similar.

Type I marine collagen is derived from fish skin. Type II collagen is derived from bovine cartilage. In both cases, these animals are intended for consumption.

Le collagène marin, de type I, est issu de la peau de poissons. Le collagène de type II est quant à lui issu de cartilages bovins. Dans les deux cas, ces animaux sont destinés à la consommation.

It is important to note that:

• The quality and effectiveness of collagen peptides can vary depending on the source, extraction process, and purity of the product.

• The advantages and disadvantages of each type of collagen can vary based on the quality, source, and extraction method.

• Therefore, it is important to choose high-quality and reliable sources of collagen supplements to maximize their benefits.

• These choices have influenced the formulation of Synergy6. Our scientific approach has allowed us to combine a specific molecule choice with a precise and optimized dosage to ensure maximum effect on joints.

• Hyaluronic acid is a polysaccharide (a complex sugar) naturally present in the human body (found in all our cells), particularly in the joints, eyes, and skin. It has a chain-like structure and can retain large amounts of water, allowing it to play a crucial role in lubricating joints (synovial fluid and tendon sheaths), hydrating and maintaining the elasticity of the skin, and regulating intraocular pressure in the eye.

• Did you know? Hyaluronic acid can retain up to 1000 times its own weight in water, making it an excellent moisturizer for the skin.

Hyaluronic acid (HA) is a natural component of synovial fluid that lubricates the joints. Hyaluronic acid is also present in articular cartilage and is synthesized by chondrocytes, the cells that produce and maintain the cartilage matrix. Hyaluronic acid also plays a role in tendon function. Tendons are surrounded by a synovial sheath, which also produces hyaluronic acid. This substance helps to lubricate the tendons and reduce friction between the tendons and surrounding structures, such as bones and muscles. Additionally, it penetrates the cartilage and actively participates in maintaining healthy cartilage. It also has anti-inflammatory properties and plays a crucial role in maintaining joint homeostasis.

Supplementing with hyaluronic acid can be beneficial for athletes and active individuals, particularly in helping to maintain joint and connective tissue health. Here are some potential benefits:

• Reduction of joint pain: Hyaluronic acid can help improve joint mobility and flexibility, which can be particularly useful for athletes who put significant stress on their joints.

• Hyaluronic acid is an important component of connective tissues such as tendons, ligaments, and cartilage. Supplementing with hyaluronic acid can help strengthen these tissues and prevent injuries.

• Reduction of oxidative damage: Thanks to the antioxidant properties of HA, a reduction in damage caused by free radicals during exercise can be expected.

Harpagophytum, also known as devil’s claw, is a plant native to South Africa. Indigenous tribes in this region have traditionally used the roots of this plant to treat ailments such as joint pain, headaches, menstrual pain, and gastrointestinal disorders. Over time, this plant has become popular in natural medicine in Europe and North America. In the 20th century, studies began to examine its potential effects on health, particularly on joint pain and inflammation.

This plant is primarily used to treat joint pain, particularly osteoarthritis and rheumatoid arthritis. The active compounds in the plant, notably harpagosides, have anti-inflammatory and analgesic properties recognized by the WHO and can help reduce pain and inflammation in the joints.

Here are some potential benefits of harpagophytum*:

• Relieves joint pain

• Reduces inflammation

• Improves mobility by reducing pain and inflammation

• Relieves back pain caused by inflammation of muscles and joints

• Aids digestion as it can help stimulate the production of gastric juices

*A study published in the Journal of Alternative and Complementary Medicine in 2008 examined the effect of harpagophytum on pain and physical function in patients with knee osteoarthritis. The results showed that taking a harpagophytum extract for eight weeks had beneficial effects on pain and physical function compared to a placebo.

Another study published in the journal Phytomedicine in 2002 examined the effect of harpagophytum on low back pain. Participants took a harpagophytum extract for four weeks, and the results showed a significant reduction in pain compared to a placebo.

A study published in the journal Planta Medica in 1995 examined the effect of harpagophytum on inflammation in rats. The results showed that harpagophytum had significant anti-inflammatory effects.

A study published in the journal Phytotherapy Research in 2013 examined the effect of harpagophytum on pain and physical function in patients with fibromyalgia. Participants took a harpagophytum extract for 12 weeks, and the results showed a significant improvement in pain and physical function compared to a placebo.

Glucosamine is a natural substance found in the human body. It is one of the components necessary for the formation and repair of cartilage, which covers the ends of bones in joints. Glucosamine is usually extracted from the shells of shellfish such as shrimp, crabs, and lobsters, although synthetic versions also exist. It is often combined with chondroitin, another substance found in cartilage.

Glucosamine sulfate stimulates cartilage cells to naturally synthesize collagen and hyaluronic acid.

Chondroitin is a natural substance found in cartilage, the connective tissue that covers the ends of bones in joints. It is part of proteoglycans, molecules that give cartilage its strength and elasticity. Chondroitin is naturally present in animal tissues, primarily in the cartilage of marine animals such as sharks, rays, and fish. The extraction of chondroitin is typically done from these animal sources.

Chondroitin is believed to work by reducing inflammation in the joints, promoting the production of new cartilage components, and inhibiting enzymes that degrade cartilage. It may also help improve joint lubrication. Chondroitin is often combined with glucosamine in dietary supplements intended for the treatment of osteoarthritis. Both substances are considered “chondroprotective,” meaning they are supposed to help preserve and repair damaged cartilage.

We recommend that you consume it at a fixed time in the morning and assimilate it over a period of no more than one hour.

On days you practice sport, we recommend that you consume it 2 to 3 hours before your session to ensure optimal bioavailability.

• Nous vous conseillons de le consommer à heure fixe le matin et de l’assimiler sur une période d’une heure maximum. Pas besoin d’une prise à jeun
• Les jours durant lesquels vous pratiquez votre sport, nous vous recommandons de le consommer 2 à 3 heures avant votre séance pour assurer une biodisponibilité optimale, c’est-à-dire que c’est le moment où on retrouve le pic de concentration maximum dans le sang. Et le fait de faire du sport sur ce créneau permet un apport maximal au niveau des articulations. Cela ne remet pas en cause l’efficacité si on ne le prend pas à ce moment là.